Regulation of translation initiation by FRAP/mTOR
نویسندگان
چکیده
منابع مشابه
Regulation of translation initiation by herpesviruses.
Viruses are dependent upon the host cell protein synthesis machinery, thus they have developed a range of strategies to manipulate host translation to favour viral protein synthesis. Consequently, the study of viral translation has been a powerful tool for illuminating many aspects of cellular translational control. Although much work to date has focused on translational regulation by RNA virus...
متن کاملRegulation of Antioxidant Metabolism by Translation Initiation Factor 2α
Oxidative stress and highly specific decreases in glutathione (GSH) are associated with nerve cell death in Parkinson's disease. Using an experimental nerve cell model for oxidative stress and an expression cloning strategy, a gene involved in oxidative stress-induced programmed cell death was identified which both mediates the cell death program and regulates GSH levels. Two stress-resistant c...
متن کاملRegulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2alpha.
Initiation of translation from most cellular mRNAs occurs via scanning; the 40 S ribosomal subunit binds to the m(7)G-cap and then moves along the mRNA until an initiation codon is encountered. Some cellular mRNAs contain internal ribosome entry sequences (IRESs) within their 5'-untranslated regions, which allow initiation independently of the 5'-cap. This study investigated the ability of cell...
متن کاملRegulation of Internal Ribosomal Entry Site-mediated Translation by Phosphorylation of the Translation Initiation
Initiation of translation from most cellular mRNAs occurs via scanning; the 40 S ribosomal subunit binds to the mG-cap and then moves along the mRNA until an initiation codon is encountered. Some cellular mRNAs contain internal ribosome entry sequences (IRESs) within their 5 -untranslated regions, which allow initiation independently of the 5 -cap. This study investigated the ability of cellula...
متن کاملMetabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells.
Recent findings have demonstrated that the branched-chain amino acid leucine can activate the translational regulators, phosphorylated heat- and acid-stable protein regulated by insulin (PHAS-I) and p70 S6 kinase (p70S6k), in an insulin-independent and rapamycin-sensitive manner through mammalian target of rapamycin (mTOR), although the mechanism for this activation is undefined. It has been pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genes & Development
سال: 2001
ISSN: 0890-9369
DOI: 10.1101/gad.887201